In evaluating a patient for potential atopic dermatitis, which laboratory value is expected to be elevated?

In the context of atopic dermatitis, elevated levels of Immunoglobulin E (IgE) are commonly associated with this condition. Atopic dermatitis is characterized by an underlying immunologic response that often involves hyperproduction of IgE in response to environmental allergens. This immunologic pathway reflects a Th2 cell-mediated response, which is predominant in allergic conditions.

When a patient has atopic dermatitis, the immune system tends to overreact to allergens, leading to increased IgE synthesis. The elevation of IgE can be seen in skin tests for allergens as well and is often used as a marker in the diagnosis and management of atopic diseases, including allergies and asthma.

In contrast, while IgA plays a role in mucosal immunity, it is not typically elevated in cases of atopic dermatitis. Basophils, which release histamine and other mediators involved in hypersensitivity reactions, may be activated in allergic responses but do not serve as a direct marker for atopic dermatitis like IgE does. Neutrophils, which are primarily involved in acute inflammation and bacterial infections, do not have a specific correlation with atopic dermatitis symptoms or diagnosis either.

Thus, the elevation of IgE is a hallmark feature in evaluating and diagnosing atopic dermatitis,